An assessment is made of the potenial of the material under test to produce dermal irritation in a relevant animal model. The rabbit is the preferred test animal.

 Methods of irritation including：

Animal intracutaneous (intradermal) reactivity test, Skin sensitization test, Ocular irritation test, oral mucosa innitation test, Penile irritation test, Rectal irritation test, Vaginal irritation test

Up：Test for sensitization

Down：Tests for systemic toxicity