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Test for in vitro cytotoxicity
ISo 10993-5 describes test methods to assess the in vitro cytotoxicity of medical devices. These methods specify the incubation of cultured cells in contact with a device and/or extracts of device either directly or through diffusion. These methods are designed to determine the biological response of mammalian cells in vitro using appropriate biological parameters.
Methods of cytotoxicity including: Extracts, Direct contact, Indirect contact