The primary function of genotoxicity tests is to inverstigate,using test cells or organisms, the potential of products to induce genetic changes in man that may be transmitted via the germ cells to future generations. Scientific data generally support the hypothesis that DNA damage in somatic cells is a critical event in the initiation of cancer. Such damage can result in mutations, and tests to detect genotoxic activity may also identify chemicals that have the potential to lead to carcinogenesis. Thus, some of the tests are useful for the inverstigation of putative carcinogenic activity.
Methods of test for genotoxicity including：
In vitro mammalian chromosome aberration test,
Salmonella typhimurium reverse mutation assay,
In vitro mammalian cell gene mutation test,
Micronucleus test of bone marrow cell
Up：Pyrogenicity test
Down：Test for carcinogenicity
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